The National Institute for Health and Clinical Excellence (NICE) recomends naftidrofuryl oxalate as a treatment option for intermittent claudication in invividuals with peripheral arterial disease for whom vasodilator therapy is considered after consideration of other treatment options.

NICE recommends that therapy should be initiated with the least costly licenced preparation. Cilostazol, pentoxifylline, and inositol nicotinate have not been recommended for treatment of intermittent claudication in people with peripheral arterial disease.